Natesto: Understanding Its Effects on Kidney Health in Men with Hypogonadism

Written by Dr. Jonathan Peterson, Updated on March 28th, 2025

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Introduction to Natesto

Natesto is a testosterone nasal gel approved by the FDA for the treatment of hypogonadism in men, a condition characterized by low testosterone levels. This innovative delivery method offers a convenient alternative to traditional testosterone therapies, such as injections or patches. As with any medication, understanding its effects on various bodily systems, including the kidneys, is crucial for patients and healthcare providers.

Understanding Kidney Function

The kidneys play a vital role in maintaining overall health by filtering waste and excess fluids from the blood, regulating electrolytes, and producing hormones that control blood pressure and stimulate red blood cell production. Any substance that affects kidney function can have significant implications for overall health.

Natesto and Kidney Health: What We Know

Research on the direct impact of Natesto on kidney function is limited, as most studies focus on its efficacy in increasing testosterone levels and its overall safety profile. However, testosterone therapy in general has been associated with potential effects on kidney function. Some studies suggest that testosterone can influence kidney function by affecting blood pressure and fluid balance, which are critical for kidney health.

Potential Risks and Considerations

While Natesto itself has not been directly linked to kidney damage, it is essential for men with pre-existing kidney conditions to approach testosterone therapy with caution. Elevated testosterone levels can lead to increased red blood cell production, which may thicken the blood and potentially strain the kidneys. Additionally, testosterone can affect blood pressure, another factor that can impact kidney health.

Monitoring and Management

For American men considering or currently using Natesto, regular monitoring of kidney function is advisable. This can be achieved through routine blood tests that measure creatinine levels and estimate glomerular filtration rate (eGFR), which are indicators of kidney function. Men with a history of kidney disease or those at risk should discuss these concerns with their healthcare provider before starting Natesto.

Lifestyle Factors and Kidney Health

In addition to monitoring, maintaining a healthy lifestyle can support kidney health while using Natesto. This includes staying hydrated, eating a balanced diet low in sodium and processed foods, exercising regularly, and avoiding smoking and excessive alcohol consumption. These lifestyle choices can help mitigate potential risks associated with testosterone therapy.

Consulting Healthcare Providers

Before starting Natesto, it is crucial for men to have a thorough discussion with their healthcare provider about their medical history, including any kidney-related issues. This conversation should cover the potential benefits and risks of Natesto, as well as any necessary monitoring and follow-up care.

Conclusion

While Natesto offers a promising option for men with low testosterone, understanding its potential impact on kidney health is essential. By staying informed and working closely with healthcare providers, American men can make educated decisions about their treatment options and take proactive steps to protect their kidney health. Regular monitoring and a healthy lifestyle can help ensure that the benefits of Natesto are maximized while minimizing potential risks to kidney function.

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